NAD+

Plasma Concentration Studies

NAD+

Nicotinamide Adenine Dinucleotide

Coenzyme I

Beta-NAD

A critical dinucleotide coenzyme that activates sirtuins and supports mitochondrial function, studied for cellular energy metabolism in research models.

Certificate of Analysis

Third Party Tested by Freedom Diagnostics

99.67%
Purity
Variant
NAD+ 500mg
Lot #
Blue Cap
Labeled
500mg
Actual
508.37mg
Tested
Apr 14, 2026
View COA

Compound Information

Technical specifications

Molecular Profile

NAD+ Structure

Type
Dinucleotide coenzyme
CAS Number
53-84-9
Molecular Formula
C21H27N7O14P2
Molecular Weight (Cu)
663.43 g/mol
Components
Nicotinamide + Adenine + Ribose + Phosphate
Biological Targets

Enzyme Interactions

Essential cofactor for multiple enzyme families.

Sirtuins
SIRT1-7 deacetylases
PARPs
DNA repair enzymes
CD38/CD157
NAD+ glycohydrolases
Oxidoreductases
500+ enzymes
Physical Properties

Where It Stands

Stability and storage requirements.

Appearance
White to off-white powder
Solubility
Freely soluble in water
Storage (powder)
-20°C, protected from light
Solution stability
Use promptly, refrigerate

Sources & References

Peer-reviewed research

Frontiers in Endocrinology

Association of Human Whole Blood NAD+ Contents With Aging

2022 • DOI: 10.3389/fe..

PMID: 35370948

Yang F, et al.

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Trends in Cell Biology

NAD+ and Sirtuins in Aging and Disease

2014 • PMID: 24786309

Imai S, Guarente L

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Antioxidants

A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour...

2019 • PMID: 31508207

Grant R, et al.

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Circulation

NAD+ Metabolism in Cardiac Health, Aging, and Disease

2021 • PMID: 34843394

Abdellatif M, et al.

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Nature Metabolism

NAD+ Homeostasis in Health and Disease

2020 • PMID: 32694684

Katsyuba E, et al.

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Circulation Research

Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular...

2018 • PMID: 30355082

Kane AE, Sinclair DA

  • View Source
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Research Verification

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