5-Amino-1MQ

Plasma Concentration Studies

5-Amino-1MQ

5-Amino-1-Methylquinolinium

5A1MQ

NNMTi

CAS: 42464-96-0

A selective small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) that modulates NAD+ salvage and lipogenesis pathways in preclinical metabolic research models. Premium Research Peptide.

Certificate of Analysis

Third Party Tested by Freedom Diagnostics

coming soon!

Compound Information

Technical specifications

Molecular Profile

What Is 5-Amino-1MQ?

Type
Small molecule NNMT inhibitor
CAS Number
42464-96-0
Molecular Weight
159.21 g/mol (cation)
Salt Form
286.11 g/mol (iodide salt)
Formula
C₁₀H₁₁N₂⁺ (cation)
Appearance
Brown to reddish-brown solid
Storage Requirements

Stability Information

Soluble in DMSO. Avoid repeated freeze-thaw. Aliquot after reconstitution

Lyophilized (powder)

-20°C • stable 24+ months

Short-term storage

2-8°C • up to 30 days

Reconstituted

2-8°C • use within 7-14 days

Sources & References

Peer-reviewed research

Journal of Medicinal Chemistry

Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase

2017 • DOI: 10.1021/acs.jmedchem.7b00389 ...

PMID: 28548833

Neelakantan H, Wang HY, Vance V et...

  • View Source

Biochemical Pharmacology

Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase...

2018 • DOI: 10.1016/j.bcp.2...

PMID: 29155147

Neelakantan H, Vance V, Wetzel MD et...

  • View Source

Biochemical Pharmacology

Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and...

2019 • DOI: 10.1016/j.bcp.2

PMID: 30753815

Neelakantan H, Brightwell CR, Graber...

  • View Source

Scientific Reports

Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body...

2021 • DOI: 10.1038/s41598-021-85051-6...

PMID: 33707534

Sampson CM, Dimet AL, Neelakantan...

  • View Source

Journal of Pharmaceutical and Biomedical Analysis

Development & validation of LC-MS/MS assay for 5-amino-1-methyl quinolinium in rat plasma: Applicatio...

2021 • DOI: 10.1016/j.jpba...

PMID: 34304009

Awosemo O, Neelakantan H,...

  • View Source

Journal of Obstetrics and Gynaecology

Small molecule inhibitor of nicotinamide N-methyltransferase shows anti-proliferative activity in...

2021 • DOI: 10.1080/01443615.2020.1854696...

PMID: 33645410

Akar S, Duran T, Azzawri AA et al.

  • View Source
All the research peptides you need, with the peace of mind and research community at your fingertips.
Discover More

Research Verification

Pèptido Labs sells research peptides exclusively to qualified researchers and laboratories for in vitro and laboratory use. Please confirm before continuing.

By proceeding you affirm the statements above are true. Products are not for human or veterinary use, not for use in diagnostic procedures, and have not been evaluated by the U.S. Food and Drug Administration.