Metabolic Peptide

5-Amino-1MQ

5-Amino-1-Methylquinolinium

5A1MQ

NNMTi

A selective small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) that modulates NAD+ salvage and lipogenesis pathways in preclinical metabolic research models. Premium Research Peptide.

Certificate of Analysis

Third Party Tested by Freedom Diagnostics

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Compound Information

Technical specifications

🔬 Molecular Profile

What Is 5-Amino-1MQ?

Type

Small molecule NNMT inhibitor

CAS Number

42464-96-0

Molecular Weight

159.21 g/mol (cation)

Salt Form

286.11 g/mol (iodide salt)

Formula

C₁₀H₁₁N₂⁺ (cation)

Appearance

Brown to reddish-brown solid

🧊 Storage Requirements

Stability Information

Soluble in DMSO

Avoid repeated freeze-thaw

Aliquot after reconstitution

Lyophilized (powder)

-20°C • stable 24+ months

Short-term storage

2-8°C • up to 30 days

Reconstituted

2-8°C • use within 7-14 days

Sources & References

Peer-reviewed research

Journal of Medicinal Chemistry

Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase

2017 • DOI: 10.1021/acs.jmedchem.7b00389 ...

PMID: 28548833

Neelakantan H, Wang HY, Vance V et...

Biochemical Pharmacology

Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase...

2018 • DOI: 10.1016/j.bcp.2...

PMID: 29155147

Neelakantan H, Vance V, Wetzel MD et...

Biochemical Pharmacology

Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and...

2019 • DOI: 10.1016/j.bcp.2

PMID: 30753815

Neelakantan H, Brightwell CR, Graber...

Scientific Reports

Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body...

2021 • DOI: 10.1038/s41598-021-85051-6...

PMID: 33707534

Sampson CM, Dimet AL, Neelakantan...

Journal of Pharmaceutical and Biomedical Analysis

Development & validation of LC-MS/MS assay for 5-amino-1-methyl quinolinium in rat plasma: Applicatio...

2021 • DOI: 10.1016/j.jpba...

PMID: 34304009

Awosemo O, Neelakantan H,...

Journal of Obstetrics and Gynaecology

Small molecule inhibitor of nicotinamide N-methyltransferase shows anti-proliferative activity in...

2021 • DOI: 10.1080/01443615.2020.1854696...

PMID: 33645410

Akar S, Duran T, Azzawri AA et al.

Scientific Reports

Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice

2022 • DOI: 10.1038/s41598-021-03670-5...

PMID: 35013352

Dimet-Wiley A, Wu Q, Wiley JT et al.

Diabetes, Obesity and Metabolism

Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunction

2024 • DOI: 10.1111/dom.15879...

PMID: 39161060